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Effect of sulglycotide in the prevention of duodenal ulcer relapse
V De Conca1, S Saccomanno, M Dodero
1Division of Gastroenterology, Galliera Hospital, Genova, Italy.
Objective:
To evaluate the effectiveness of sulglycotide, a gastroprotective drug, as maintenance treatment for patients with duodenal ulcer.
Design:
A randomized double-blind study.
Methods:
A total of 119 patients with recently healed duodenal ulcers were randomly allocated, in a double-blind fashion, to receive sulglycotide 200 mg twice daily (60 patients) or placebo (59 patients) for 1 year. Patients underwent clinical assessment every third month and endoscopy at 6 and 12 months, or earlier if relapse was suspected.
Results:
The cumulative endoscopic relapse rates, compared using the log rank test, were 37 and 52% after 6 and 12 months, respectively, in the sulglycotide group and 62 and 71% (P = 0.03), respectively, in the placebo group.
Conclusions:
Sulglycotide is moderately effective as a maintenance treatment for duodenal ulcer disease.
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