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Cholestatic jaundice induced by spontaneous disruption of an oestrogen implant
T E Bowling1, M al-Adnani, D B Silk
1Department of Gastroenterology, Central Middlesex Hospital, London, UK.
Objective:
To describe the case of a women with cholestatic jaundice induced by the spontaneous fragmentation of an oestrogen implant.
Patient:
A 48-year-old woman, who presented with jaundice, pruritus and a flu-like illness 2 weeks after the insertion of a 100 mg oestradiol implant into her right buttock.
Interventions:
At presentation the implant was removed and found to be fragmented. Investigations revealed an oestradiol level of 1548 pmol/l and an oestrogen-induced cholestatic jaundice.
Results:
After removal of the implant and progesterone therapy, the patients symptoms resolved.
Conclusion:
This is the first reported case of cholestatic jaundice induced by a subcutaneous oestrogen implant.
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