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Pharmacologic immunosuppression: cure or curse?

A Wahrenberger

    Critical Care Nursing Quarterly
    |February 1, 1995
    PubMed
    Summary

    Organ transplantation is a vital treatment, but immunosuppressive drugs like cyclosporine have side effects. Future advancements aim to improve these therapies, making transplantation more of a cure and less of a curse.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Transplant Medicine

    Background:

    • Organ transplantation is a leading treatment for end-stage organ diseases.
    • The success of transplantation relies heavily on pharmacologic immunosuppression.
    • Current immunosuppressive regimens carry significant side effects.

    Purpose of the Study:

    • To review traditional, current, and future immunosuppressive agents used in organ transplantation.
    • To examine the usage and side effects of these immunosuppressive drugs.
    • To discuss the evolving landscape of immunosuppression in transplantation.

    Main Methods:

    • Literature review of immunosuppressive agents.
    • Discussion of drug classes including corticosteroids, azathioprine, cyclosporine, antilymphocyte preparations, FK 506, rapamycin, mycophenolate mofetil, brequinar, deoxyspergualin, and monoclonal antibodies.
    • Analysis of drug efficacy and adverse effects.

    Main Results:

    • Traditional immunosuppressants include corticosteroids and azathioprine.
    • Current agents include cyclosporine and antilymphocyte preparations.
    • Future agents under investigation include FK 506, rapamycin, mycophenolate mofetil, brequinar, deoxyspergualin, and novel monoclonal antibodies.

    Conclusions:

    • Immunosuppression is essential for transplant success but requires lifelong management.
    • While not a complete cure, transplantation offers significant benefits.
    • Ongoing research in immunosuppression promises to enhance outcomes and reduce the burden on patients.

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