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Related Experiment Videos

An old antibiotic for a new multiple-resistant Enterococcus faecium?

F Moreno1, J H Jorgensen, M H Weiner

  • 1Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7881.

Diagnostic Microbiology and Infectious Disease
|September 1, 1994
PubMed
Summary
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A multidrug-resistant Enterococcus faecium caused a serious bloodstream infection in a lung cancer patient. Successful treatment involved doxycycline and catheter removal, highlighting alternative therapeutic options.

Area of Science:

  • Infectious Diseases
  • Internal Medicine
  • Oncology

Background:

  • Enterococci are a significant cause of hospital-acquired infections.
  • High-level antibiotic resistance in enterococci complicates treatment strategies.
  • Patients with compromised immune systems, such as those with small cell lung cancer, are at increased risk.

Observation:

  • A 68-year-old male patient with a history of small cell lung cancer developed bacteremia.
  • The causative agent was identified as a strain of Enterococcus faecium.
  • The enterococcal isolate exhibited resistance to vancomycin, ampicillin, aminoglycosides, quinolones, and macrolides.

Findings:

  • The patient's bacteremia was successfully treated with doxycycline.
  • Removal of an infected central venous catheter was a crucial part of the treatment regimen.

Related Experiment Videos

  • This case demonstrates a viable treatment option for vancomycin-resistant Enterococcus faecium infections.

    • Implications:

    • Highlights the growing challenge of multidrug-resistant enterococci in clinical settings.
    • Suggests doxycycline as a potential therapeutic agent for specific resistant enterococcal infections.
    • Emphasizes the importance of source control, such as catheter removal, in managing nosocomial bloodstream infections.