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Drug targeting with nanoparticles

J Kreuter1

  • 1Institut für Pharmazeutische Technologie, Johann Wolfgang Geothe-Universität Frankfurt/Main, Germany.

European Journal of Drug Metabolism and Pharmacokinetics
|July 1, 1994
PubMed
Summary
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Nanoparticle drug delivery systems can be coated to alter their distribution in the body. This modification allows for targeted delivery of drugs to specific sites like tumors or the brain.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Nanoparticles are colloidal polymeric particles (<1000 nm) used for drug delivery.
  • Typically, nanoparticles distribute to reticuloendothelial system organs after intravenous injection.
  • Drug distribution can be modified by nanoparticle surface coatings.

Purpose of the Study:

  • To discuss how nanoparticle coatings influence body distribution.
  • To explore potential mechanisms behind altered nanoparticle distribution.
  • To highlight applications of coated nanoparticles for targeted drug delivery.

Main Methods:

  • Review of existing literature on nanoparticle coatings and biodistribution.
  • Analysis of how surfactants and physiological components affect nanoparticle fate.

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  • Discussion of targeting strategies for specific tissues.

    • Main Results:

    • Nanoparticle surface modification with surfactants or physiological components alters biodistribution.
    • Mechanisms for altered distribution involve interactions with biological systems.
    • Coated nanoparticles show potential for targeted delivery to tumors, brain, and inflamed tissues.

    Conclusions:

    • Surface modification is a key strategy to control nanoparticle biodistribution.
    • Targeted drug delivery using nanoparticles can be achieved through tailored coatings.
    • Further research into coating mechanisms can optimize nanoparticle-based therapies.