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Rat strain differences in catechol carcinogenicity to the stomach

H Tanaka1, M Hirose, A Hagiwara

  • 1First Department of Pathology, Nagoya City University Medical School, Japan.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|February 1, 1995
PubMed
Summary

Wistar, Lewis, and Sprague-Dawley (SD) rats are highly susceptible to catechol-induced stomach cancer. WKY rats show significantly lower susceptibility, indicating strain-dependent carcinogenic effects of this phenolic antioxidant.

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Area of Science:

  • Toxicology
  • Carcinogenesis
  • Animal Models

Background:

  • Catechol is a phenolic compound with antioxidant properties.
  • Understanding the carcinogenic potential of catechol is crucial for risk assessment.

Purpose of the Study:

  • To compare the carcinogenic effects of catechol across different rat strains.
  • To identify rat strains with varying susceptibility to catechol-induced tumors.

Main Methods:

  • Male Wistar, WKY, Lewis, and SD rats (30 per group) were fed a diet containing 0.8% catechol for 104 weeks.
  • Histopathological examination was performed to assess tumor induction.

Main Results:

  • High incidences of glandular stomach adenocarcinomas were observed in Wistar (67%), Lewis (73%), and SD (77%) rats.

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  • WKY rats exhibited a significantly lower incidence (10%) of glandular stomach adenocarcinomas.
  • Catechol also induced forestomach papillomas (20%) and squamous cell carcinomas (3%) in SD rats.

    • Conclusions:

    • Wistar, Lewis, and SD rats are significantly more susceptible to catechol-induced glandular stomach adenocarcinomas than WKY rats.
    • Catechol demonstrates weak carcinogenic activity in the forestomach of SD rats.
    • Rat strain is a critical factor in determining susceptibility to catechol carcinogenesis.