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Adult growth hormone deficiency
J O Jørgensen1, J Müller, J Møller
1Medical Department M (Endocrinology and Diabetes), Aarhus Kommunehospital, Denmark.
Hormone Research
|January 1, 1994
Summary
Adult growth hormone (GH) deficiency causes serious health issues, including higher cardiovascular mortality and poor body composition. GH replacement therapy effectively reverses these detrimental effects, improving overall health and wellbeing.
Area of Science:
- Endocrinology
- Metabolic Medicine
Background:
- Adult growth hormone (GH) deficiency presents with significant clinical manifestations.
- Previous studies have documented the effects of GH deficiency and GH therapy.
Purpose of the Study:
- To summarize the clinical consequences of untreated adult GH deficiency.
- To evaluate the impact of GH replacement therapy on these abnormalities.
Main Methods:
- Review of existing clinical reports and studies on adult GH deficiency.
- Analysis of data concerning the effects of GH substitution therapy.
Main Results:
- Untreated GH deficiency is linked to increased cardiovascular mortality, reduced physical capacity, altered body composition (increased fat mass, decreased lean mass), and impaired psychological wellbeing.
- GH replacement therapy demonstrably improves cardiovascular health, exercise capacity, body composition, and psychological status.
- The primary side effect of GH therapy is transient, dose-dependent fluid retention.
Conclusions:
- GH deficiency in adults has profound and widespread clinical consequences.
- GH replacement therapy offers significant benefits, largely alleviating the negative impacts of GH deficiency.
- GH therapy is a safe and effective treatment for adult GH deficiency.