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Related Experiment Videos

Restricted postexercise pulmonary diffusion capacity does not impair maximal transport for O2

B Hanel1, P S Clifford, N H Secher

  • 1Copenhagen Muscle Research Center, Department of Anesthesia, Rigshospitalet, University of Copenhagen, Denmark.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1994
PubMed
Summary

Exercise reduces pulmonary diffusion capacity for carbon monoxide (DLco) and arterial O2 tension. A second exercise bout did not further impact DLco, suggesting central blood volume, not edema, influences these changes.

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Area of Science:

  • Physiology
  • Exercise Physiology
  • Pulmonary Function

Background:

  • Pulmonary diffusion capacity for carbon monoxide (DLco) can decrease after exercise.
  • The factors influencing this postexercise reduction are not fully understood.

Purpose of the Study:

  • To investigate if a second bout of rowing affects the postexercise reduction in DLco.
  • To determine if postexercise DLco changes impact arterial O2 tension during maximal exercise.

Main Methods:

  • DLco, membrane diffusion capacity, and pulmonary capillary blood volume were measured before and after exercise.
  • Arterial O2 tension and saturation were monitored during maximal exercise.
  • The effect of a second exercise bout and furosemide administration on DLco was assessed.

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Main Results:

  • DLco, membrane diffusion capacity, and pulmonary capillary blood volume were significantly reduced after exercise.
  • A second bout of exercise did not alter DLco or membrane diffusion capacity.
  • Arterial O2 tension and saturation decreased during both exercise bouts.
  • Furosemide did not affect DLco, suggesting central blood volume involvement over pulmonary edema.

Conclusions:

  • Postexercise reduction in DLco is influenced by factors related to central blood volume, not pulmonary edema.
  • Repeated exercise bouts do not exacerbate the reduction in DLco.
  • Reduced arterial O2 tension during maximal exercise is a consistent finding, independent of DLco changes from a second bout.