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Methotrexate in psoriatic arthritis
Y N Singh1, K K Verma, A Kumar
1Department of Medicine, All India Institute of Medical Sciences, New Delhi.
Abstract:
Thirty three patients with psoriatic arthritis were treated with starting dose of 7.5 mg of methotrexate orally, every week for a period of 6 months to 7 years (mean 2.2 years) along with non-steroidal anti-inflammatory agents. The dose of methotrexate during the course of therapy ranged 5 to 15 mg/week (mean 7.8 mg). There was complete to partial remission in arthritis and psoriatic skin lesions in 94% (31) patients. No response was noticed in 2 patients. Regular monitoring of haematological, renal and liver function tests was done. No significant side effects of the drug, requiring discontinuation of the therapy, were seen during the treatment. Methotrexate can be used early in the course of psoriatic arthritis with good results.
Insights
Early methotrexate treatment for psoriatic arthritis showed significant results. Most patients experienced remission in arthritis and skin lesions with minimal side effects.
Area of Science:
- Rheumatology
- Dermatology
Background:
- Psoriatic arthritis is a chronic inflammatory condition affecting joints and skin.
- Early intervention is crucial for managing psoriatic arthritis effectively.
Purpose of the Study:
- To evaluate the efficacy and safety of early methotrexate treatment in psoriatic arthritis patients.
Main Methods:
- Thirty-three patients with psoriatic arthritis received weekly oral methotrexate (mean dose 7.8 mg/week) for a mean of 2.2 years.
- Concomitant use of non-steroidal anti-inflammatory agents was permitted.
- Regular monitoring of hematological, renal, and liver function tests was performed.
Main Results:
- 94% of patients (31/33) achieved complete to partial remission of both arthritis and psoriatic skin lesions.
- Two patients showed no response to the treatment.
- No significant adverse events necessitated treatment discontinuation.
Conclusions:
- Methotrexate is an effective and safe treatment option for early-stage psoriatic arthritis.
- Early initiation of methotrexate therapy can lead to favorable outcomes in managing psoriatic arthritis.