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Sickle cell syndromes in and around Bardoli
The Journal of the Association of Physicians of India
|November 1, 1994
Summary
Sickle cell disease affects students from backward communities and hospital patients, with limb pain and weakness being common symptoms. Prevalence was 1.74% in hospital admissions, with HbSS and HbAS being most common.
Area of Science:
- Hematology
- Genetics
- Public Health
Background:
- Sickle cell disease is a genetic blood disorder.
- Understanding its prevalence in specific communities is crucial for targeted interventions.
Purpose of the Study:
- To determine the prevalence of sickle cell trait and disease.
- To identify common clinical manifestations and associated tribes/castes.
Main Methods:
- Sickling tests were conducted on 130 students from a backward community school.
- Hospitalized patients (Jan '81-June '82) were studied for sickle cell syndrome prevalence.
- Hemoglobin electrophoresis and clinical observations were performed.
Main Results:
- 24 out of 130 students (18.5%) showed sickling.
- Hospital prevalence of sickle cell syndrome was 1.74%.
- Common presentations included limb pains and weakness; HbSS and HbAS were most frequent genotypes. Specific tribes showed higher prevalence.
Conclusions:
- Sickle cell disease is prevalent in certain tribal and caste groups.
- Early diagnosis and management are essential, especially in at-risk populations.
- Further research into genetic factors and clinical management is warranted.