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Ventricular late potentials after thrombolysis

A K Kar1, A Chatterjee, S Roy

  • 1Dept of Cardiology, Institute of Postgraduate Medical Education & Research Centre, Calcutta.

The Journal of the Association of Physicians of India
|August 1, 1994
PubMed
Summary
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Thrombolytic therapy, using intravenous streptokinase, significantly reduced the occurrence of late potentials (LPs) in patients following acute myocardial infarction (AMI). This suggests early treatment can decrease risks associated with LPs.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Late potentials (LPs) are high-frequency, low-amplitude signals prolonging the QRS complex.
  • LPs post-acute myocardial infarction (AMI) correlate with increased risk of ventricular tachyarrhythmias and sudden cardiac death (SCD).
  • Thrombolytic therapy for AMI is known to reduce ventricular tachyarrhythmias and SCD incidence.

Purpose of the Study:

  • To investigate if thrombolytic therapy administered during acute myocardial infarction (AMI) reduces the incidence of late potentials (LPs).

Main Methods:

  • A study involving 52 male patients (41-46 years) with first anterior wall AMI.
  • Thirty patients received intravenous streptokinase (IVSK) within 6 hours of chest pain onset, alongside conventional therapy.
  • Twenty-two patients received conventional therapy only (control group).

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  • Groups were comparable in age, CKMB, hypertension, diabetes, smoking, beta-blocker use, and ejection fraction.

    • Main Results:

    • Late potentials (LPs) were detected in 8 out of 30 patients receiving IVSK.
    • 13 out of 22 patients in the control group tested positive for LPs.
    • The difference in LP incidence between the IVSK and control groups was statistically significant (p < 0.02).

    Conclusions:

    • Early administration of thrombolysis in anterior AMI significantly diminishes the incidence of late potentials (LPs).
    • This finding supports the role of early reperfusion therapy in mitigating arrhythmogenic substrate formation after AMI.