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Secondary amyloidosis complicating psoriasis
G P Wittenberg1, J R Oursler, M S Peters
1Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
Journal of the American Academy of Dermatology
|March 1, 1995
Summary
Secondary amyloidosis complicating psoriasis is rare but aggressive. This study identified 28 cases, finding this condition can be fatal, underscoring the need for awareness in managing psoriasis patients.
Area of Science:
- Rheumatology
- Dermatology
- Pathology
Background:
- Amyloidosis involves extracellular fibrillar protein deposition.
- Secondary amyloidosis arises from chronic inflammation or infection.
- Psoriasis-associated secondary amyloidosis is exceptionally rare, with only 18 prior reports.
Purpose of the Study:
- To characterize secondary amyloidosis in patients with psoriasis.
- To analyze clinical features and outcomes of this rare complication.
Main Methods:
- Retrospective review of Mayo Clinic cases (1950-1992) of coexisting psoriasis and amyloidosis.
- Literature review of similar cases.
- Histopathologic and immunohistochemical analysis for amyloid typing.
Main Results:
- Identified 28 cases of coexisting psoriasis and amyloidosis.
- In five cases, psoriasis was the sole preceding inflammatory condition.
- Confirmed amyloid A subtype in two cases; Congo red staining in four.
Conclusions:
- Amyloidosis associated with psoriasis is an aggressive disease.
- The condition may be fatal, necessitating vigilant monitoring.
- Further research is needed to understand pathogenesis and improve outcomes.