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Clostridial infection in children

I Brook1

  • 1Department of Pediatrics, Georgetown University School of Medicine, Washington, DC.

Journal of Medical Microbiology
|February 1, 1995
PubMed
Summary

Clostridium species are significant causes of pediatric infections, frequently isolated from abscesses and other serious conditions. These bacteria often occur in mixed infections, highlighting the need for comprehensive anaerobic microbiology in children.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Clostridium species are anaerobic bacteria with diverse pathogenic potential.
  • Understanding their role in pediatric infections is crucial for effective diagnosis and treatment.

Purpose of the Study:

  • To survey the prevalence and types of Clostridium species isolated from pediatric specimens.
  • To identify common infection sites and associated predisposing conditions.
  • To analyze co-infections involving Clostridium species in children.

Main Methods:

  • Retrospective analysis of 1543 specimens submitted to anaerobic microbiology laboratories.
  • Identification and quantification of Clostridium species isolates.
  • Correlation of isolates with clinical data, infection sites, and co-pathogens.

Main Results:

  • Clostridium species were isolated from 7.0% of pediatric specimens (107/1543), with 96 children affected.
  • Clostridium perfringens and unidentified Clostridium species were most common.
  • Abscesses, peritonitis, and bacteremia were frequent sources, often associated with underlying conditions like immunodeficiency and malignancy.
  • Mixed infections were common, with anaerobic cocci, Bacteroides spp., and Escherichia coli frequently isolated alongside Clostridium species.

Conclusions:

  • Clostridium species play a significant role in pediatric infections, particularly in serious conditions like abscesses and peritonitis.
  • The presence of predisposing factors increases the risk of Clostridium-associated infections in children.
  • Comprehensive anaerobic culture and identification are essential for managing polymicrobial infections in pediatric patients.

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