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Related Experiment Videos

Do alpha-blockers have a role in lower urinary tract dysfunction in multiple sclerosis?

J I O'Riordan1, C Doherty, M Javed

  • 1Department of Neurology, St. Vincent's Hospital, Dublin, Ireland.

The Journal of Urology
|April 1, 1995
PubMed
Summary

Indoramin improved bladder emptying in men with multiple sclerosis by blocking alpha 1-adrenergic receptors. This treatment offers potential for managing lower urinary tract dysfunction in multiple sclerosis patients.

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Area of Science:

  • Neurology
  • Urology
  • Pharmacology

Background:

  • Lower urinary tract dysfunction significantly impacts multiple sclerosis patients' quality of life.
  • Alpha 1-adrenergic receptors at the bladder neck may contribute to urinary retention and reduced flow rates in multiple sclerosis.

Purpose of the Study:

  • To investigate the efficacy of indoramin, a selective alpha 1-adrenergic receptor antagonist, in improving bladder emptying.
  • To test the hypothesis that indoramin can alleviate lower urinary tract symptoms in multiple sclerosis.

Main Methods:

  • A randomized, placebo-controlled study involving 18 men with multiple sclerosis.
  • Evaluation of peak and mean urinary flow rates, residual volume, and symptom scores before and after 4 weeks of treatment.

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Main Results:

  • The indoramin group showed a 41% mean improvement in peak flow rate, versus a 7.4% deterioration in the placebo group (p < 0.05).
  • Both groups experienced improvements in residual volume.
  • Patients receiving indoramin reported greater symptom relief.

Conclusions:

  • Selective alpha 1-adrenergic receptor blockade with indoramin can enhance bladder emptying in men with multiple sclerosis.
  • Modulating alpha 1-receptors presents a potential therapeutic strategy for managing lower urinary tract dysfunction in multiple sclerosis.