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Vesical dysfunction in systemic sclerosis (scleroderma)

M Lazzeri1, P Beneforti, G Benaim

  • 1Department of Urology, University of Ferrara, Italy.

The Journal of Urology
|April 1, 1995
PubMed
Summary
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Systemic sclerosis can affect the urinary tract. This study found bladder dysfunction and histological changes in women with scleroderma, indicating detrusor areflexia and arterial lesions.

Area of Science:

  • Urology
  • Rheumatology
  • Pathology

Background:

  • Systemic sclerosis is a connective tissue disease affecting multiple organs.
  • Urinary tract involvement in systemic sclerosis is infrequently reported.
  • The bladder's role in systemic sclerosis requires further investigation.

Purpose of the Study:

  • To investigate the functional and histological involvement of the bladder in women with systemic sclerosis.
  • To assess urodynamic parameters and detrusor muscle histology.

Main Methods:

  • Urodynamic assessment was performed on 9 women with systemic sclerosis.
  • Histopathological examination of bladder tissue was conducted.
  • Analysis focused on voiding volumes, residual volumes, and detrusor muscle integrity.

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Main Results:

  • Three patients exhibited low voiding volumes (<100 ml) with significant residual urine.
  • Four patients presented with detrusor areflexia during cystometrograms.
  • Histological examination revealed arterial lesions and capillary bed derangement in the detrusor of patients with areflexia.

Conclusions:

  • The bladder is functionally and histologically involved in systemic sclerosis.
  • Detrusor areflexia in these patients is associated with microvascular and arterial pathology.
  • These findings highlight the importance of evaluating urinary tract function in systemic sclerosis management.