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Related Experiment Videos

Dormant microbes in interstitial cystitis

G J Domingue1, G M Ghoniem, K L Bost

  • 1Department of Urology, Tulane University, New Orleans, Louisiana.

The Journal of Urology
|April 1, 1995
PubMed
Summary
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Researchers found Gram-negative bacterial DNA and unusual filterable microbial forms in bladder biopsies from interstitial cystitis (IC) patients. This suggests a potential microbial cause for IC, a condition previously lacking a known etiology.

Area of Science:

  • Urology
  • Microbiology
  • Molecular Biology

Background:

  • Interstitial cystitis (IC) is an inflammatory bladder condition with an unknown cause.
  • Microbial links to IC are not well-established due to negative routine urine cultures.

Purpose of the Study:

  • To investigate the presence of bacterial DNA and novel microbial forms in bladder tissue of IC patients.
  • To explore potential microbial etiologies for interstitial cystitis.

Main Methods:

  • Nested PCR was used to amplify bacterial 16S rRNA genes from bladder biopsies.
  • DNA sequencing identified bacterial genera.
  • Cultures were used to isolate 0.22 micron filterable forms from biopsy tissues.

Main Results:

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  • Bacterial 16S rRNA genes were detected in 29% of IC patient biopsies, but not in controls.
  • Sequencing revealed Gram-negative bacterial DNA.
  • Unique 0.22 micron filterable forms containing nucleic acids were isolated from 100% of IC patient biopsies.

Conclusions:

  • This study provides the first evidence associating Gram-negative bacterial DNA and unique filterable forms with IC bladder tissue.
  • These findings suggest a potential, previously unrecognized microbial role in the pathogenesis of interstitial cystitis.