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Interchangeability of conjugated Haemophilus influenzae type b vaccines in infants

E L Anderson1, M D Decker, J A Englund

  • 1Department of Medicine, Saint Louis (Mo) University School of Medicine.

JAMA
|March 15, 1995
PubMed

Insights

Sequential Haemophilus influenzae type b (Hib) vaccine combinations were safe and effective. Serial administration of PRP-OMP and HbOC vaccines demonstrated comparable or superior immunogenicity to single-product regimens in infants.

Area of Science:

  • Pediatric infectious diseases
  • Vaccinology
  • Immunology

Background:

  • Haemophilus influenzae type b (Hib) conjugate vaccines are crucial for preventing invasive Hib disease.
  • Two primary conjugate vaccines, PRP-OMP and HbOC, exist, utilizing different carrier proteins.
  • Evaluating serial combinations of these vaccines is important for optimizing infant immunization schedules.

Purpose of the Study:

  • To assess the safety and immunogenicity of sequential administration of two Hib conjugate vaccines: PRP-OMP and HbOC.
  • To compare the immunogenicity of serial combinations against single-product regimens.
  • To evaluate the priming effect of unconjugated PRP at 15 months.

Main Methods:

  • A randomized, double-blind clinical trial involving 497 healthy 2-month-old infants.
  • Five different Hib vaccination regimens were administered, including serial combinations of PRP-OMP and HbOC.
  • Antibody concentrations were measured after primary series and booster doses; safety was monitored.

Main Results:

  • Significant differences in geometric mean antibody concentrations were observed among groups after the second and third immunizations, and after booster doses.
  • Serial combinations of PRP-OMP and HbOC achieved antibody concentrations equal to or greater than single-product groups.
  • No significant variations in adverse reactions were noted between the different vaccination groups.

Conclusions:

  • Sequential administration of Hib conjugate vaccines (PRP-OMP and HbOC) is safe.
  • These serial combinations are at least as immunogenic as using a single vaccine product.
  • The findings support the flexibility of using serial combinations in infant immunization schedules.
Abstract

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