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Quantitative analysis of a drug in an animal feed employing sample preparation by supercritical fluid extraction
D C Messer1, L T Taylor, W E Weiser
1Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Pharmaceutical Research
|November 1, 1994
Abstract:
A pharmaceutical agent has been quantified in a rat feed matrix wherein sample preparation was achieved by supercritical fluid extraction. Spiking levels ranged from 0.0335% to 1.12%. Pure carbon dioxide, solid phase trapping on stainless steel with acetonitrile and liquid chromatographic assay yielded recoveries greater than 90% with relative standard deviations less than 5% in all cases except for the lowest spiking level. In this case recovery was 89.6% with an RSD of 9.6.