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Related Experiment Videos

Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for

A Woods1, C Smith, M Szewczak

  • 1Department of Biological Research, Hoechst-Roussel Pharmaceuticals, Inc. Somerville, NJ 08876.

Psychopharmacology
|January 1, 1993
PubMed
Summary
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Selective serotonin re-uptake inhibitors (SSRIs) like fluoxetine significantly reduced excessive water consumption in a rat model of schedule-induced polydipsia (SIP). This finding suggests SSRIs may be effective in treating obsessive-compulsive disorder (OCD).

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Schedule-induced polydipsia (SIP) is a behavioral model characterized by excessive water intake in rats under a fixed-time feeding schedule.
  • SIP shares behavioral similarities with excessive behaviors seen in obsessive-compulsive disorder (OCD).

Purpose of the Study:

  • To investigate the effects of selective serotonin re-uptake inhibitors (SSRIs) on schedule-induced polydipsia (SIP).
  • To evaluate the potential of the SIP model for predicting compounds effective in treating OCD.

Main Methods:

  • Polydipsia was induced in food-deprived rats using a 60-second fixed-time feeding schedule for 22 days.
  • Rats exhibiting significant polydipsia were administered SSRIs (fluoxetine, clomipramine, fluvoxamine), a noradrenergic re-uptake inhibitor (desipramine), haloperidol, or diazepam.

Related Experiment Videos

  • Water consumption was monitored to assess the effects of drug administration on SIP behavior.

    • Main Results:

    • Chronic administration of fluoxetine, clomipramine, and fluvoxamine significantly decreased SIP behavior from day 15 onwards.
    • Desipramine showed a transient decrease in SIP behavior only on day 1.
    • Haloperidol and diazepam did not alter SIP behavior.

    Conclusions:

    • SSRIs effectively reduce excessive water consumption in the SIP model.
    • The SIP model may serve as a valuable preclinical tool for identifying potential therapeutic agents for OCD.