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Updated: Aug 5, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
Published on: May 2, 2018
[A novel extended-spectrum beta-lactamase in a ceftazidime-resistant isolate of E. coli]
Abstract:
A novel extended-spectrum beta-lactamase (ESbla) encoded on a plasmid of approximately 7.5kb, conferring resistance to beta-lactams tested except cefoxitin and imipenem, was found in a ceftazidime-resistant isolate of E. coli form our hospital. The resistance to beta-lactams was transferred by conjugation to E. coli JP559 together with the aminoglycosides and sulfonamide resistance. Clavulanate, one of beta-lactamase inhibitors, inhibited its activity. This ESbla gene hybridized neither with an intra-genic fragment of SHV-1 nor with that of TEM-1. The molecular origin of that novel ESbla needed to be further studied.
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