Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic histopathological changes in biliary pancreatitis

M Isogai1, A Yamaguchi, A Hori

  • 1Department of Surgery, Ogaki Municipal Hospital, Japan.

The American Journal of Gastroenterology
|March 1, 1995
PubMed
Summary

Biliary pancreatitis causes acute liver damage, including hepatocyte necrosis and cholangitis, often due to impacted gallstones. This liver injury likely explains elevated serum transaminase levels in these patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimisation of Radiation Therapy in Bladder Preservation Therapy for Patients With Clinical Stage T2N0M0 Bladder Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Cost utility analysis of pharmacist counseling care for breast cancer chemotherapy outpatients.

Die Pharmazie·2019
Same author

Combating 'fake news' and social stigma after the Fukushima Daiichi Nuclear Power Plant incident-the importance of accurate longitudinal clinical data.

QJM : monthly journal of the Association of Physicians·2019
Same author

Death of the sole doctor at Takano Hospital 6 years after the Fukushima nuclear crisis-who is responsible for health care delivery in the Fukushima disaster zone?

QJM : monthly journal of the Association of Physicians·2017
Same author

Mutant botrocetin-2 inhibits von Willebrand factor-induced platelet agglutination.

Journal of thrombosis and haemostasis : JTH·2017
Same author

Structured Frameworks to Increase the Transparency of the Assessment of Benefits and Risks of Medicines: Current Status and Possible Future Directions.

Clinical pharmacology and therapeutics·2015

Area of Science:

  • Gastroenterology
  • Hepatology
  • Pathology

Background:

  • Elevated serum transaminases suggest gallstone etiology in acute pancreatitis.
  • Hepatic histopathological changes in biliary pancreatitis remain under-investigated.

Purpose of the Study:

  • Observe acute-stage hepatic histopathology in biliary pancreatitis.
  • Elucidate the mechanism behind transaminase elevation in biliary pancreatitis.

Main Methods:

  • Analyzed liver biopsy specimens (26 patients) and biliary tract gross pathology (62 patients) from patients with biliary pancreatitis.
  • Correlated findings with gallstone presence and biliary diseases.

Main Results:

  • Hepatocyte necrosis (96.2%) and acute cholangitis (65.4%) were primary light microscopic findings.

Related Experiment Videos

  • Electron microscopy revealed disorganized liver plates and biliary material retention.
  • Gallstones were identified in 56.5% (impacted) and 21.0% (floating) of patients.

    • Conclusions:

    • Hepatic changes include acute inflammatory hepatocyte necrosis, degeneration, and cholangitis, primarily caused by impacted ampullary stones.
    • Serum transaminase elevation likely reflects hepatocyte necrosis and/or degeneration.