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Pigmented renal cell carcinoma

T Kamishima1, T Fukuda, I Emura

  • 1Second Department of Pathology, Niigata University School of Medicine, Japan.

The American Journal of Surgical Pathology
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

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This study presents a rare case of pigmented renal cell carcinoma. The tumor cells contained neuromelanin, a pigment typically found in neurons, indicating an unusual accumulation.

Area of Science:

  • Nephrology
  • Oncology
  • Pathology

Background:

  • Renal cell carcinoma (RCC) is a common kidney malignancy.
  • Pigmentation within RCC is exceptionally rare, with unclear etiology.
  • Clear-cell RCC is the most frequent histological subtype.

Observation:

  • A unique case of a yellow, soft renal tumor was identified.
  • Microscopic examination revealed clear-cell RCC with scattered brown pigment in tumor cells.
  • Ultrastructural analysis characterized the pigment's granules.

Findings:

  • The intracytoplasmic pigment demonstrated ultrastructural features resembling lipofuscin.
  • Histochemical staining (Masson-Fontana after bleaching) differentiated the pigment from lipofuscin.
  • The pigment was identified as neuromelanin, a pigment not typically found in renal tumors.

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Implications:

  • This case highlights an unprecedented finding of neuromelanin accumulation in renal cell carcinoma.
  • The presence of neuromelanin suggests novel cellular pathways or origins in this rare tumor.
  • Further research is warranted to understand the mechanism and clinical significance of pigment accumulation in RCC.