[Physicochemical interactions and mode of storage of Diprivan]

Only few publications consider physio-chemical interactions and stability of propofol. On the basis of current experience, this agent is safe for use in polypropylene or polypropylene/polystyrene syringes, diluted 1 in 5 in 5% dextrose if necessary. The potential hazards are as follows: 1. Propofol may undergo oxidation when not stored under nitrogen, or when in contact with oxidizing agents (active ingredients or excipients of other preparations). 2. The emulsion may be destabilised by contact with mineral or organic cations (calcium, magnesium, dibasic amino acids etc.) or acids (citric acid etc.). 3. Losses of propofol may occur by adsorption-diffusion (surface adherence combined with penetration of plastic material) during storage in PVC bags or during administration by means of PVC infusion sets. Most of these hazards have still to be evaluated under controlled conditions.