[Diprivan: efficient concentrations in relation to physiological parameters and associated drugs]

According to the literature there is a large inter-individual variability, with blood concentrations often ranging from 1 to 3-fold. These variations between patients reduce the value of recommended concentrations. In practice it is more important to titrate the dose according to the clinical response (or lack of response), rather than to blindly follow the various dosage regimens proposed and, with which it is theoretically possible to rapidly reach and then maintain the desired propofol concentration. In practice, what is the point of carefully maintaining a propofol concentration of 3.5 micrograms.mL-1 (theoretical maintenance level for an average patient), if the latter (failing to comply with the usual range of concentrations) needs a propofol level of 6 micrograms.mL? In practice, we must titrate!