[Modes of administration of Diprivan]

Administration of propofol using standard syringe pumps has become routine in anaesthesia. The marketing of syringe pumps adapter for anaesthesia (high flow rate enabling a bolus injection and a slower rate for maintenance), allows an easier setting up of total intravenous anaesthesia. Computer-aided infusion of propofol will undoubtedly expand in the near future, as a result of the forthcoming marketing of computer-controlled infusion pumps and of improvement in the recognition of accurate individual pharmacokinetic parameters. This computer-aided infusion will be based on a blood concentration criterion, and no longer on a dosage regimen given to the patient. A closed loop regulatory system remains in the domain of research.