[Increased viability of skin flaps using naftidrofuryl. An experimental study in the Wistar rat]

The effect of a vasodilator (naftidrofuryl) was evaluated in an experimental study in rats concerning the viability of a skin flap. The reference flap is a dorsal skin flap deliberately shaped very long in order to obtain necrosis of its distal extremity. This necrosis is measurable and sufficiently reproducible. Using a comparative study between a control group of ten rats and a group of rats treated by intraperitoneal injections of naftidrofuryl for ten days, the authors demonstrated a significant difference between necrosis in the two groups. Naftidrofuryl treatment increases the length of the viable part of the skin flap in rats. This product achieves a kind of medicinal autonomy much easier than a surgical autonomy.