Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects on platelet function by human interferon-beta in carcinoma patients

P Ferroni1, M Roselli, A Diodati

  • 1Department of Experimental Medicine, University of Rome La Sapienza, Italy.

Anticancer Research
|November 1, 1994
PubMed
Summary

Human interferon-beta (Hu IFN-beta) therapy increased platelet aggregation in cancer patients. This suggests Hu IFN-beta may directly influence bone marrow, affecting platelet function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PD-L1 thresholds predict efficacy of immune checkpoint inhibition in first-line treatment of advanced gastroesophageal adenocarcinoma. A systematic review and meta-analysis of seven phase III randomized trials.

ESMO open·2024
Same author

Extracellular volume measured by whole body CT scans predicts chronic cardiotoxicity in breast cancer patients treated with neoadjuvant therapies based on anthracyclines: A retrospective study.

Breast (Edinburgh, Scotland)·2024
Same author

Ankle sprain and podoscopic footprint pattern in female volleyball players.

Acta orthopaedica Belgica·2023
Same author

Impact of body composition on survival of PD-1/PD-L1-treated metastatic gastro-esophageal junction/gastric cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·2022
Same author

One year of surgical mask testing at the University of Bologna labs: Lessons learned from data analysis.

Separation and purification technology·2022
Same author

A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma.

Critical reviews in oncology/hematology·2020

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Platelet function is crucial in hemostasis and thrombosis.
  • Neoplastic disorders can significantly alter hematological parameters, including platelet function.
  • Interferon-beta (IFN-beta) is an immunomodulatory cytokine with potential therapeutic applications.

Purpose of the Study:

  • To investigate the impact of a therapeutic course of human interferon-beta (Hu IFN-beta) on platelet function in patients with neoplastic disorders.
  • To assess changes in platelet count, volume, size, and in vitro aggregation.
  • To explore potential correlations with serum cytokine levels.

Main Methods:

  • 10 patients with neoplastic disorders received intramuscular Hu IFN-beta (6 x 10(6) IU) every other day for 2 weeks.

Related Experiment Videos

  • Platelet aggregation, count, packed volume, and size were measured pre-treatment and weekly during treatment.
  • Serum levels of IFN-gamma, IL-6, IL-1 beta, and GM-CSF were assessed.

    • Main Results:

    • All patients exhibited increased in vitro platelet aggregation after the first week, persisting through the second week.
    • The most pronounced effect on aggregation was observed with ADP and collagen inducers.
    • No significant changes in serum IFN-gamma, IL-6, IL-1 beta, or GM-CSF levels were noted, though a parallel rise in IL-1 beta and/or GM-CSF with platelet count was observed.

    Conclusions:

    • Therapeutic Hu IFN-beta administration enhances platelet aggregation in patients with neoplastic disorders.
    • The findings suggest a potential direct influence of Hu IFN-beta on bone marrow, modulating platelet function.
    • Further research is warranted to elucidate the precise mechanisms underlying IFN-beta's effects on hematopoiesis and platelet activity.