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Related Experiment Videos

Pastes: what do they contain? How do they work?

R D Juch1, T Rufli, C Surber

  • 1Spirig AG, Pharmazeutische Präparate, Egerkingen, Schweiz.

Dermatology (Basel, Switzerland)
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Classical zinc oxide pastes lack absorptive features, contrary to common belief. Hydrophilic cream pastes, however, effectively absorb water, making them suitable for drying the skin.

Area of Science:

  • Pharmaceutical Sciences
  • Dermatology
  • Materials Science

Background:

  • Pastes are semisolid preparations with high concentrations of powdered materials in a vehicle.
  • Clinically, pastes are expected to absorb exudates, but pharmacopoeial formulations like zinc oxide pastes may not possess this feature.
  • Lipophilic vehicles in traditional pastes can prevent water absorption.

Purpose of the Study:

  • To evaluate the absorptive capacity of various powders and paste formulations.
  • To investigate the relationship between paste composition and its ability to absorb water or exudates.

Main Methods:

  • Powder absorption was measured using the Enslin method.
  • Paste absorption was determined by weight difference before and after water incubation.

Related Experiment Videos

  • A standardized procedure was employed for paste preparation and testing.

    • Main Results:

    • Zinc oxide and kaolin powders exhibited the highest water absorption (1000 mg/g).
    • Corn starch and titanium dioxide showed lower absorption (700 mg/g and 450 mg/g, respectively).
    • Two-phase lipophilic pastes demonstrated no absorptive capacity, while three-phase hydrophilic cream pastes showed significant water uptake.

    Conclusions:

    • Traditional two-phase pastes, including zinc oxide formulations, are occlusive and lack absorptive properties.
    • Lipophilic pastes are best suited for protecting intact skin from moisture and exudates.
    • Hydrophilic three-phase cream pastes effectively absorb water, aligning with the expectation of drying properties.