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Related Experiment Videos

Topical haemotherapy for leg ulcers

B Triquet1, P Ruffieux, C Mainetti

  • 1Department of Dermatology, University Hospital, Geneva, Switzerland.

Dermatology (Basel, Switzerland)
|January 1, 1994
PubMed
Summary
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Topical haemotherapy (THT) using autologous blood rapidly promotes healing in chronic leg ulcers by removing dead tissue and stimulating granulation. This safe and inexpensive treatment facilitates skin grafting for improved wound closure.

Area of Science:

  • Regenerative Medicine
  • Wound Healing Biology
  • Dermatology

Background:

  • Chronic atonic leg ulcers present a significant clinical challenge.
  • Growth factors and proteases in blood are known to play roles in wound repair.
  • Current treatments for chronic leg ulcers can be invasive or have limited efficacy.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical haemotherapy (THT) using autologous heparinized blood for chronic atonic leg ulcers.
  • To assess the rate of debridement and granulation tissue formation induced by THT.
  • To determine the feasibility and tolerability of THT in a clinical setting.

Main Methods:

  • Fifteen patients with chronic atonic leg ulcers were treated with topical application of autologous heparinized blood under a hydrocolloidal dressing.

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  • THT was administered every other day.
  • Wound healing progress, including debridement of fibrinonecrotic material and granulation tissue coverage, was monitored.

    • Main Results:

    • Significant removal of fibrinonecrotic material (30%) was observed after the first THT application.
    • After a mean of 9 THT applications, granulation tissue covered up to 75% of the ulcer surface, enabling autologous skin grafting.
    • No local or systemic side-effects were reported during the treatment period.

    Conclusions:

    • Topical haemotherapy (THT) is a feasible, well-tolerated, easy, and inexpensive treatment for chronic leg ulcers.
    • THT rapidly induces granulation tissue formation, facilitating wound closure and potential skin grafting.
    • The therapeutic effect of THT may be attributed to growth factors and proteases released from blood cells.