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Eruptive hamartomatous clear-cell acanthomas

G Burg1, T Würsch, J Fäh

  • 1Department of Dermatology, University of Zurich, Switzerland.

Dermatology (Basel, Switzerland)
|January 1, 1994
PubMed
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A rare case of eruptive hamartomatous clear-cell acanthoma (CCA) presented with over 100 papules. This extensive presentation of CCA is highly unusual, offering insights into rare dermatological conditions.

Area of Science:

  • Dermatology
  • Histopathology
  • Oncology

Background:

  • Clear-cell acanthoma (CCA) is a benign epithelial skin tumor.
  • Multiple instances of CCA are uncommon, typically presenting with fewer than 20 lesions.
  • The etiology and full spectrum of CCA presentations require further investigation.

Observation:

  • A 38-year-old female patient developed over 100 solid papules on her extremities and trunk over a decade.
  • Histological examination confirmed the characteristic features of clear-cell acanthoma.
  • Systemic investigations ruled out any associated extracutaneous abnormalities.

Findings:

  • The patient's condition, characterized by numerous hamartomatous CCA lesions, is exceptionally rare.
  • This case represents the highest reported number of CCA lesions, exceeding previous records of approximately 20.

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  • The presentation is termed 'eruptive hamartomatous CCA' due to its unique and widespread nature.

    • Implications:

    • This case expands the known clinical spectrum of clear-cell acanthoma.
    • Understanding rare presentations like eruptive hamartomatous CCA is crucial for accurate diagnosis and management.
    • Further research may elucidate specific triggers or genetic factors contributing to such extensive hamartomatous proliferation.