Drosophila Forkhead homologues are expressed in CD34+/HLA-DR- primitive human hematopoietic progenitors
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Updated: Jul 11, 2026

Assaying Blood Cell Populations of the Drosophila melanogaster Larva
Published on: November 11, 2015
R Hromas1, M Klemsz, L Amaravadi
1Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202.
Abstract:
The Forkhead gene (FKH) regulates morphogenesis in Drosophila. It is the prototype of a new family of transcriptional activators. We used the polymerase chain reaction (PCR) to analyze the expression pattern of this new transcriptional regulatory gene family in primitive hematopoeitic progenitors. Partially degenerate oligonucleotides to two conserved amino acid sequences of this family were used to prime a PCR amplification of cDNA synthesized from CD34+/HLA-DR- hematopoietic cells. Known and novel FKH genes were found to be expressed in these cells.
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