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TAME-esterase activity during a prolonged attack of asthma
A H Subratty1, M Y Yan, L H Shun
1Medical and Health Sciences Department, Faculty of Science, University of Mauritius, Réduit.
International Journal of Clinical Pharmacology and Therapeutics
|November 1, 1994
Summary
Serum N-alpha-tosyl-L-arginine methyl ester (TAME)-esterase activity did not change in patients with prolonged asthma attacks after salbutamol treatment. This suggests TAME-esterase is linked to early, not prolonged, asthma responses.
Area of Science:
- Biochemistry
- Pulmonology
- Clinical Medicine
Background:
- Asthma attacks involve complex physiological and biochemical changes.
- N-alpha-tosyl-L-arginine methyl ester (TAME)-esterase activity has been implicated in early asthmatic responses.
Purpose of the Study:
- To investigate serum TAME-esterase activity in patients experiencing prolonged asthma attacks.
- To determine if salbutamol nebulization affects serum TAME-esterase levels in these patients.
Main Methods:
- Serum samples were collected from asthma patients during prolonged attacks.
- TAME-esterase activity was measured before and after salbutamol nebulization.
Main Results:
- No significant change in serum TAME-esterase activity was observed pre- or post-salbutamol nebulization.
- The findings indicate TAME-esterase is not elevated during prolonged asthma attacks.
Conclusions:
- Serum TAME-esterase activity is associated with the early asthmatic response.
- TAME-esterase is not a significant marker for prolonged asthma attacks or their response to salbutamol.