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Coenzyme Q: potentially useful index of bioenergetic and oxidative status of spermatozoa
A G Angelitti1, L Colacicco, C Callà
1Dipartimento di Urologia "U. Bracci", Università degli Studi La Sapienza, Rome, Italy.
Clinical Chemistry
|February 1, 1995
Abstract:
The concentration of coenzyme Q10 (CoQ10), a key intermediate of the mitochondrial respiratory chain, was determined in spermatozoa of 13 fertile subjects, 8 potentially fertile patients, and 12 infertile patients. CoQ10 concentrations were significantly higher (P < 0.001) in infertile patients than in fertile and potentially fertile subjects. The difference between potentially fertile and fertile subjects was also significant (P < 0.001). We propose that a decrease in consumption of CoQ10 in both infertile and potentially fertile populations is due to an autoregulatory mechanism of ATP production.