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Developmental changes in the function of hematopoietic stem cells

P M Lansdorp1

  • 1Terry Fox Laboratory, British Columbia Cancer Agency, Department of Medicine, University of British Columbia, Vancouver, Canada.

Experimental Hematology
|March 1, 1995
PubMed
Summary
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Stem cells are not immortal, as previously thought. Their functional properties and telomere length change during development, challenging the traditional definition of stem cells.

Area of Science:

  • Developmental biology
  • Hematopoiesis
  • Stem cell biology

Background:

  • Colony-forming unit-spleen (CFU-S) cells are found in various hematopoietic tissues throughout development.
  • The traditional view posits stem cells as immortal and invariant.
  • Variable numbers of stem cells exist across different developmental stages.

Purpose of the Study:

  • To discuss developmental aspects of stem cell biology.
  • To re-evaluate stem cell definitions in light of new findings.
  • To explore stem cell biology within transplantation contexts.

Main Methods:

  • Review of existing literature on stem cell ontogeny.
  • Analysis of functional properties of candidate stem cells during development.
  • Examination of telomere length changes in hematopoietic cells.

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Main Results:

  • Purified candidate stem cells exhibit significant functional changes during ontogeny.
  • Hematopoietic cells show a decrease in mean telomere length during development.
  • These findings challenge the concept of stem cells as immortal and invariable.

Conclusions:

  • The concept of stem cells as a single, immortal cell type is challenged by developmental data.
  • Stem cell definitions need to accommodate ontogenetic changes in function and telomere length.
  • Understanding developmental stem cell biology is crucial for transplantation biology.