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Related Experiment Videos

Evaluation of thyroid functions in critically ill infants

N K Anand1, V Chandra, R S Sinha

  • 1Department of Pediatrics, Safdarjang Hospital, New Delhi.

Indian Pediatrics
|October 1, 1994
PubMed
Summary

Thyroid function tests in infants with severe illness show decreased T3 and T4 levels, especially near death. These changes may be adaptive, so interpret thyroid tests cautiously in non-thyroidal illness.

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Area of Science:

  • Pediatric Endocrinology
  • Critical Care Medicine
  • Neonatology

Background:

  • Non-thyroidal illness (NTI) can significantly alter thyroid function.
  • Understanding these alterations is crucial for managing critically ill infants.
  • The impact of NTI on thyroid hormone levels and its correlation with mortality in infants requires further investigation.

Purpose of the Study:

  • To evaluate the impact of severe acute systemic illness on thyroid function in infants.
  • To assess the correlation between altered thyroid function and mortality in this population.
  • To determine if thyroid indices at admission can predict prognosis in critically ill infants.

Main Methods:

  • Studied 30 infants with severe acute systemic illness and 30 matched healthy controls.

Related Experiment Videos

  • Measured total serum triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) at admission and recovery/near death.
  • Analyzed thyroid indices in relation to age, sex, nutritional status, and C-reactive protein.

    • Main Results:

    • Infants with severe illness had significantly lower serum T3 levels (0.62 ± 0.63 ng/ml) compared to controls (1.90 ± 0.62 ng/ml) at admission, with normal T4 and TSH.
    • Serum T3 and T4 levels increased upon recovery.
    • T3 and T4 values were significantly reduced near death compared to admission levels (p < 0.001).

    Conclusions:

    • Thyroid function tests should be interpreted with caution in infants with non-thyroidal illness.
    • Observed changes in thyroid indices likely represent a temporary adaptive mechanism to limit catabolism during stress.
    • Thyroid indices at admission did not differ significantly between infants who survived and those who died, precluding their use as prognostic indicators.