Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection
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Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: July 1, 2013
O A Anzala1, N J Nagelkerke, J J Bwayo
1Department of Medical Microbiology, University of Nairobi, Kenya.
Abstract:
From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.
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