Related Experiment Videos
Progressive supranuclear palsy: neuropathologically based diagnostic clinical criteria
S J Collins1, J E Ahlskog, J E Parisi
1Department of Neurology, Mayo Clinic, Rochester, MN 55905.
Journal of Neurology, Neurosurgery, and Psychiatry
|February 1, 1995
Summary
This study analyzed 12 progressive supranuclear palsy (PSP) cases, revealing atypical clinical signs beyond classic symptoms. Developing new criteria may improve premortem diagnosis of this neurodegenerative disorder.
Area of Science:
- Neurology
- Neuroscience
- Pathology
Background:
- Progressive supranuclear palsy (PSP) is a neurodegenerative disease with specific neuropathological criteria.
- Clinical diagnosis during life can be challenging due to varied presentations.
Purpose of the Study:
- To retrospectively analyze clinical and neuropathological findings in confirmed PSP cases.
- To develop improved premortem diagnostic criteria for PSP.
Main Methods:
- Identified Mayo Clinic postmortem cases meeting PSP neuropathological criteria.
- Re-examined necropsy material to confirm PSP diagnosis in 12 cases.
- Conducted retrospective clinical analysis of documented patient signs.
Main Results:
- Confirmed 12 cases of PSP neuropathologically.
- Documented numerous atypical clinical findings, including absence of gaze palsy, asymmetry, dystonia, apraxia, myoclonus, chorea, eyelid apraxia, and respiratory disturbance.
- Only 8 of 12 patients received a definite clinical PSP diagnosis during life.
Conclusions:
- PSP presents with a wider range of clinical signs than previously described.
- Retrospective analysis facilitated the development of new clinical criteria for premortem PSP diagnosis.
- Emphasized differentiating PSP from other akinetic-rigid disorders.