Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Streptococcus mitis infection in newborns

J T Adams1, R G Faix

  • 1Department of Pediatrics and Communicable Diseases, University of Michigan Medical Center, Ann Arbor 48109-0254.

Journal of Perinatology : Official Journal of the California Perinatal Association
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Raw Milk Quality Tests.

Journal of food protection·2019
Same author

Evaluating retinopathy of prematurity screening guidelines for 24- to 27-week gestational age infants.

Journal of perinatology : official journal of the California Perinatal Association·2014
Same author

Evolving blood pressure dynamics for extremely preterm infants.

Journal of perinatology : official journal of the California Perinatal Association·2014
Same author

Synthesis of antimalarials; synthesis of certain 1,5- and 1,8-naphthyridine derivatives.

Journal of the American Chemical Society·2010
Same author

Maternal and transplacental pharmacokinetics of cefazolin.

Obstetrics and gynecology·2002
Same author

Antithrombotic therapy in pediatrics: time for higher levels of evidence.

The Journal of pediatrics·2001

Streptococcus mitis can cause severe neonatal infections, contrary to previous assumptions about viridans group Streptococcus. Early identification and appropriate antibiotic treatment, potentially including vancomycin, are crucial for infant survival.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Neonatal infections caused by viridans group Streptococcus are often considered less severe than those from classic pathogens.
  • Limited data exists on the specific clinical impact of individual Streptococcus viridans species in neonates.

Purpose of the Study:

  • To investigate the clinical significance and outcomes of neonatal infections caused by Streptococcus mitis.
  • To assess the antibiotic susceptibility patterns of S. mitis isolates from neonatal sepsis cases.

Main Methods:

  • Case series reporting on six infants with S. mitis isolated from blood cultures.
  • Analysis of patient demographics, clinical presentation, hematologic findings, and treatment outcomes.
  • In vitro antibiotic susceptibility testing of bacterial isolates.

Related Experiment Videos

Main Results:

  • All six infants were infected within the first three days of life, with five being preterm and three having low birth weights.
  • Hematologic abnormalities were frequently observed, and two infants succumbed to the infection.
  • Antibiotic susceptibility testing revealed resistance to penicillin and ampicillin in three isolates and gentamicin resistance in two.

Conclusions:

  • Streptococcus mitis, not typically part of normal skin flora, can cause severe neonatal disease and should not be dismissed as a contaminant.
  • Prompt recognition and consideration of alternative antibiotics like vancomycin are recommended for severe S. mitis or S. viridans neonatal infections unresponsive to penicillin.