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Insulin-like growth factor-I in celiac disease
B Weile1, P A Krasilnikoff, A Giwercman
1Department of Pediatrics, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Journal of Pediatric Gastroenterology and Nutrition
|November 1, 1994
Summary
Insulin-like growth factor I (IGF-I) levels significantly change with dietary modifications in children with celiac disease. Monitoring IGF-I can aid in diagnosing celiac disease by reflecting growth impacts.
Area of Science:
- Pediatric Gastroenterology
- Endocrinology
- Immunology
Background:
- Celiac disease is an autoimmune disorder triggered by gluten ingestion.
- Physiopathological mechanisms, including growth disturbances, require further elucidation.
- Insulin-like growth factor I (IGF-I) plays a crucial role in growth and development.
Purpose of the Study:
- To investigate the role of insulin-like growth factor I (IGF-I) changes in the diagnosis and management of celiac disease.
- To correlate IGF-I fluctuations with different dietary phases (gluten-containing, gluten-free, gluten challenge) in children.
Main Methods:
- Longitudinal follow-up of IGF-I levels in 21 children suspected of celiac disease.
- Diagnosis of celiac disease based on European Society of Paediatric Gastroenterology and Nutrition criteria.
- Dietary interventions included gluten-free diet, gluten challenge, and return to gluten-free diet.
Main Results:
- Children with celiac disease showed a significant IGF-I increase (+1.54 mM/month) on a gluten-free diet.
- Gluten challenge in celiac children led to a significant IGF-I decrease (-1.11 mM/month).
- Non-celiac children challenged with gluten exhibited an age-appropriate IGF-I increase (+0.29 mM/month).
Conclusions:
- Significant IGF-I level changes correlate with dietary gluten exposure in celiac disease.
- IGF-I monitoring can serve as a supplementary diagnostic tool for celiac disease.
- IGF-I changes reflect the degree of growth retardation associated with celiac disease.