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Anticardiolipin antibodies in autoimmune thyroid disease
J J Díez1, R A Doforno, P Iglesias
1Department of Endocrinology, Hospital La Paz, Madrid, Spain.
Journal of Clinical & Laboratory Immunology
|January 1, 1993
Summary
This study found no significant association between anticardiolipin antibodies and autoimmune thyroid disease (ATD). Anticardiolipin antibody levels did not correlate with thyroid function or disease progression in patients with ATD.
Area of Science:
- Immunology
- Endocrinology
- Rheumatology
Background:
- Anticardiolipin antibodies are associated with various autoimmune conditions.
- The relationship between anticardiolipin antibodies and autoimmune thyroid disease (ATD) requires further investigation.
Purpose of the Study:
- To investigate the prevalence and potential association of anticardiolipin antibodies (IgG and IgM) in patients with autoimmune thyroid disease (ATD).
- To compare antibody levels in ATD patients with those in non-autoimmune thyroid disease and healthy controls.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to detect IgG and IgM anticardiolipin antibodies.
- Study included 69 ATD patients (Graves' disease, Hashimoto's thyroiditis), 43 non-ATD patients, and 72 healthy controls.
Main Results:
- No statistically significant differences in IgG or IgM anticardiolipin antibody prevalence were found between ATD patients, non-ATD patients, and healthy controls.
- Anticardiolipin antibody levels did not correlate with thyroid autoantibody titers, thyroid hormone levels, or thyrotropin levels.
- No correlation was observed between anticardiolipin antibodies and patient demographics or disease characteristics.
Conclusions:
- The study suggests there is no significant association between anticardiolipin antibodies and autoimmune thyroid disease.
- Further research may be needed to definitively rule out any subtle links or specific subgroups.