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Increased fearfulness of Fyn tyrosine kinase deficient mice
T Miyakawa1, T Yagi, S Watanabe
1Department of Psychology, Faculty of Letters, University of Tokyo, Japan.
Brain Research. Molecular Brain Research
|November 1, 1994
Abstract:
Fyn-deficient mice were produced by inserting the beta-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.