[Experimental studies on the morphological changes in the endocrine pancreas after gastrectomy]

I report the detailed morphological changes of the endocrine pancreas after gastrectomy, by PAP stain method, using gastrectomized rats. Regarding the number-ratio and the occupied area-ratio of the B and A cells in each Langerhans islet, there was no difference in each group. But regarding the D cell in totally gastrectomized rats, especially in EJ group (total gastrectomy, esophagojejunostomy with Braun anastomosis), the most notable morphological changes were recognized, namely the occupied area-ratio and the number-ratio of the D cell in each Langerhans islet increased to 3.57 +/- 1.64% and 11.73 +/- 3.89%. In gastrectomized rats, the structure of the B and A cells in each Langerhans islet was comparatively well-preserved. In totally gastrectomized rats, especially in EJ group, the more remarkable increase of the D cell in each Langerhans islet was recognized. It is though that because of the loss of the stomach, the secretory changes of the gut hormones and the accelerated intestinal transit and etc., the D cell increased compensatorily.