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[Fungal infection in patients with granulocytopenia. Pathogenetic, diagnostic and therapeutic aspects]
B Piatkowska-Jakubas1, A B Skotnicki
1Kliniki Hematologii Collegium Medicum Uniwersytetu Jagiellońskiego, Krakowie.
Abstract:
The invasive diagnostic procedures, use of the broad-spectrum antibiotics, adrenal corticoids, immunosuppressive and cytostatic drugs have lead to the increase in the number of fungal infections in granulocytopenic patients. For the most part fungal infections in those patients consist of the opportunistic, systemic infections in granulocytopenic patients is exceptionally frustrating because more often than not, diagnosis is very difficult to establish. The article presents some problems regarding their pathogenesis, classification, diagnosis and management.
Insights
Fungal infections are increasing in granulocytopenic patients due to invasive procedures and certain medications. Diagnosing these opportunistic infections is challenging, requiring a review of their causes, types, and treatment.
Area of Science:
- Mycology
- Immunology
- Infectious Diseases
Context:
- Increased incidence of fungal infections in granulocytopenic patients.
- Association with invasive diagnostic procedures and broad-spectrum antibiotics.
- Use of adrenal corticoids, immunosuppressive, and cytostatic drugs contributes to risk.
Purpose:
- To discuss the challenges in diagnosing and managing opportunistic fungal infections in granulocytopenic patients.
- To review the pathogenesis, classification, diagnosis, and management of these infections.
Summary:
- Granulocytopenic patients face a rising threat of opportunistic systemic fungal infections.
- Diagnosis is often difficult, posing significant clinical challenges.
- The article examines key aspects including pathogenesis, classification, diagnosis, and management strategies.
Impact:
- Highlights the critical need for improved diagnostic and management approaches for fungal infections in immunocompromised patients.
- Aims to inform clinicians about the complexities of these infections for better patient outcomes.