Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Brachytherapy in choroid tumors]

G B Pizzi1, C Marchetti, M Zemella

  • 1Divisione di Radioterapia Oncologica, Ospedale Umberto I Mestre, Venezia.

La Radiologia Medica
|December 1, 1994
PubMed
Summary

This study presents a custom brachytherapy technique using 192Iridium wires for choroidal tumors. The afterloading method ensures staff safety and delivers a favorable dose distribution for effective treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Corrigendum to "Nursing judgment in the age of generative artificial intelligence: A cross-national study on clinical decision-making performance among emergency nurses" [Int. J. Nurs. Stud. 172 (2025) 105216].

International journal of nursing studies·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Medical Physics

Background:

  • Brachytherapy is an established treatment for choroidal tumors but lacks widespread adoption due to complexity and skill requirements.
  • Current methods often utilize 60Cobalt, 106Rutenium, or 125Iodine seeds, each with specific dose distribution characteristics.
  • 192Iridium wire brachytherapy on custom plaques is a less common but viable alternative.

Purpose of the Study:

  • To describe and evaluate a custom brachytherapy technique using 192Iridium wires for treating choroidal tumors.
  • To highlight the advantages of this afterloading technique in terms of customization, accessibility, staff protection, and dose ratio.

Main Methods:

  • Developed a custom applicator using a quick-drying paste and plastic tubes for housing 192Iridium wires, sized to the affected eye.

Related Experiment Videos

  • Surgical placement of the applicator at the tumor site, followed by afterloading of 192Iridium sources.
  • Utilized preliminary dosimetric measurements to guide the placement of iridium wires within the tubes.

    • Main Results:

    • Successfully treated 4 retinoblastomas and 2 choroidal melanomas using this technique.
    • 192Iridium (320 keV) offers deeper dose penetration compared to 125Iodine (30 keV) and a more favorable surface dose than 106Rutenium (beta emitter).
    • Compared to 60Cobalt (1250 keV), 192Iridium delivers lower doses to surrounding healthy tissues.

    Conclusions:

    • This custom 192Iridium wire brachytherapy technique allows for case-specific customization and access to posterior tumor sites.
    • The afterloading approach significantly enhances radiation safety for medical staff.
    • The method achieves a beneficial depth-to-surface dose ratio, crucial for effective tumor treatment while sparing ocular structures.