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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
[Anticardiolipin antibodies in parenteral drug addicts: relationship with HIV]
J González Domínguez1, C Ortega, R Jurado
1Sección de Reumatología, Hospital Universitario Reina Sofía, Córdoba.
Abstract:
The IgG isotype of anticardiolipin antibodies (aCL) and its possible relationship with the immunodeficiency virus (HIV) were studied in 65 parenteral drug addicts (PDA). Thirty-seven patients were infected in the present study. Nineteen (51%) fulfilled diagnostic criteria of AIDS. Thirty-two of these 37 HIV-positive patients (86%) were IgG-aCL positive. Fourteen (50%) of the 28 HIV-negative patients were IgG-aCL positive. Our study reveals a lack of correlation between aCL and thrombocytopenia. None of the patients had thromboembolic complications. In AIDS patients no relationship was found between IgG-aCL levels and the presence of Pneumocystis carinii, other infections by opportunist microorganism, and clinical deterioration. Highly increased levels of IgG-aCL (> 80 GPL) were observed in three patients with AIDS and infectious endocarditis. In conclusion, given the non-specificity of aCL en PDA, it is our opinion that its measurement is of little help in daily clinical praxis.
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