Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Information-processing abnormalities as neuropsychological vulnerability indicators for schizophrenia

K H Nuechterlein1, M E Dawson, M F Green

  • 1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024-8968.

Acta Psychiatrica Scandinavica. Supplementum
|January 1, 1994
PubMed
Summary

Subtle information processing anomalies may indicate vulnerability to schizophrenia. New methods differentiate stable factors from those that mediate illness states, aiding understanding of schizophrenia's neuropsychology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Effect of treatment with paliperidone palmitate versus oral antipsychotics on frontal lobe intracortical myelin volume in participants with recent-onset schizophrenia: Magnetic resonance imaging results from the DREaM study" [Schizophr Res. 255 (2023) 195-202].

Schizophrenia research·2025
Same author

Cortical thickness, gray-white matter contrast, and intracortical myelin in first-episode schizophrenia patients treated with long-acting paliperidone palmitate versus oral antipsychotics.

Psychiatry research·2023
Same author

Loneliness is associated with mentalizing and emotion recognition abilities in schizophrenia, but only in a cluster of patients with social cognitive deficits.

Journal of the International Neuropsychological Society : JINS·2023
Same author

Effect of treatment with paliperidone palmitate versus oral antipsychotics on frontal lobe intracortical myelin volume in participants with recent-onset schizophrenia: Magnetic resonance imaging results from the DREaM study.

Schizophrenia research·2023
Same author

A combined exercise and cognitive training intervention induces fronto-cingulate cortical plasticity in first-episode psychosis patients.

Schizophrenia research·2022
Same author

MCCB cognitive profile in Spanish first episode schizophrenia patients.

Schizophrenia research·2019

Area of Science:

  • Neuropsychology
  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Subtle information processing anomalies are implicated in schizophrenia vulnerability.
  • Understanding these anomalies is crucial for identifying individuals at risk and developing targeted interventions.

Purpose of the Study:

  • To propose a conceptual framework for understanding information processing abnormalities in schizophrenia.
  • To present novel strategies for differentiating potential vulnerability factors across clinical states.

Main Methods:

  • Utilizing Continuous Performance Test (CPT) conditions with varying perceptual vs. working memory loads.
  • Employing specialized backward masking paradigms to isolate sensory-perceptual and attentional processes.
  • Investigating top-down attentional influences on sensorimotor gating to assess central executive functions.

Related Experiment Videos

Main Results:

  • Distinguishing a stable vulnerability factor from a mediating vulnerability factor within CPT tasks.
  • Separating early sensory-perceptual functions from attentional shifting using backward masking.
  • Examining the role of executive functions in modulating sensory processing via sensorimotor gating.

Conclusions:

  • Information processing anomalies represent a key aspect of schizophrenia's neuropsychological vulnerability.
  • Differentiated cognitive tasks can elucidate distinct contributing factors to schizophrenia.
  • Further research is warranted to refine these methods and their clinical applications.