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[Premedication with doxepin (author's transl)]

R Manz, C Welsch

    Praktische Anasthesie, Wiederbelebung Und Intensivtherapie
    |December 1, 1975
    PubMed
    Summary
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    Doxepin is a suitable pre-surgery medication, offering sedation, tranquilization, and pain relief while reducing secretions. While mild circulatory issues occurred in some patients, the drug was generally well-tolerated for routine use.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Cardiology

    Background:

    • Preoperative anxiety and secretion management are crucial in surgical settings.
    • Doxepin, a tricyclic antidepressant, possesses sedative and anxiolytic properties.
    • Evaluating doxepin's efficacy and safety for surgical premedication is warranted.

    Purpose of the Study:

    • To assess the effects of doxepin as a pre-anesthetic medication.
    • To evaluate its anxiety-relieving, sedative, tranquilizing, and analgesic properties.
    • To observe its impact on circulation and secretions.

    Main Methods:

    • A study involving 67 patients undergoing surgical operations.
    • Patients received doxepin as premedication prior to surgery.
    • Observed effects on circulation, anxiety levels, sedation, analgesia, and secretions.

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    Main Results:

    • Doxepin demonstrated significant sedative, tranquilizing, and analgesic effects.
    • Reduced secretion of mucus and saliva was noted.
    • Mild orthostatic circulatory dysregulation occurred in a few patients.
    • The drug was well-tolerated overall.

    Conclusions:

    • Doxepin is highly suitable for surgical premedication.
    • Its anxiolytic and physical symptom-reducing properties are beneficial.
    • It can be considered for routine administration despite minor circulatory side effects.