Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nutrition and metal toxicity

R A Goyer1

  • 1National Institute of Environmental Health Sciences, Research Triangle Park, NC 27707.

The American Journal of Clinical Nutrition
|March 1, 1995
PubMed
Summary

Toxic metals like lead, cadmium, and mercury can be more harmful when essential nutrients like calcium, iron, zinc, and selenium are deficient. These deficiencies enhance metal toxicity, impacting development and cellular processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals.

Toxicological sciences : an official journal of the Society of Toxicology·2000
Same author

Prenatal care and infant lead exposure.

The Journal of pediatrics·1997
Same author

Toxic and essential metal interactions.

Annual review of nutrition·1997
Same author

Results of lead research: prenatal exposure and neurological consequences.

Environmental health perspectives·1996
Same author

Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice.

The Journal of pharmacology and experimental therapeutics·1996
Same author

Renal tubular tumors and atypical hyperplasias in B6C3F1 mice exposed to lead acetate during gestation and lactation occur with minimal chronic nephropathy.

Cancer research·1995

Area of Science:

  • Environmental Toxicology
  • Nutritional Science
  • Biochemistry

Background:

  • Lead, cadmium, and mercury are non-essential toxic metals.
  • Their toxicity can be influenced by essential metal interactions and deficiencies.

Purpose of the Study:

  • To elucidate the mechanisms by which essential mineral deficiencies and interactions modulate the toxicity of lead, cadmium, and mercury.

Main Methods:

  • Literature review and mechanistic analysis of metal-nutrient interactions.
  • Examination of biochemical pathways affected by toxic and essential metals.

Main Results:

  • Lead toxicity is exacerbated by calcium, iron, and zinc deficiencies, affecting neurotransmission and cell metabolism.
  • Iron deficiency enhances cadmium absorption, and cadmium competes with zinc for metallothionein.
  • Selenium mitigates mercury and methylmercury toxicity through antioxidant effects and complex formation.

Conclusions:

  • Nutritional status significantly impacts the toxicological outcomes of heavy metal exposure.
  • Maintaining adequate levels of essential minerals is crucial for mitigating heavy metal toxicity.

Related Experiment Videos