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Related Experiment Videos

Endogenic nortestosterone in cattle?

H F de Brabander1, J van Hende, P Batjoens

  • 1Department of Veterinary Food Inspection, lab Chemical Analysis, RUG, Merelbeke, Belgium.

The Analyst
|December 1, 1994
PubMed
Summary
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Nortestosterone (NT) is endogenously present in pregnant cows, detectable in urine months before calving. This finding impacts veterinary meat inspection and challenges previous assumptions about NT administration in livestock.

Area of Science:

  • Veterinary Science
  • Endocrinology
  • Analytical Chemistry

Background:

  • Nortestosterone (NT) detection in animal urine typically indicated exogenous administration.
  • Previous literature lacked evidence for the endogenous presence of NT.
  • Studies suggested NT presence in stallions, boars, and pregnant cows, but required further validation.

Purpose of the Study:

  • To investigate the endogenous presence of nortestosterone (NT) in pregnant cows.
  • To determine the stage of pregnancy at which NT becomes detectable in cow urine.
  • To assess the implications for veterinary meat inspection within the EU.

Main Methods:

  • Collection and analysis of over 150 urine samples from non-treated pregnant cows.
  • Gas chromatography-mass spectrometry (GC-MS) used for NT detection.

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  • Multi-laboratory analysis (4 labs) for a subset of samples to ensure reliability.

    • Main Results:

    • Confirmed the endogenous presence of NT in the alpha form in the urine of pregnant cows.
    • NT was detectable from at least 2 months, and most likely 4-5 months, prior to parturition.
    • Results were consistent across multiple laboratories, validating the findings.

    Conclusions:

    • Endogenous nortestosterone (NT) is present in pregnant cows, detectable in urine well before calving.
    • These findings necessitate a re-evaluation of NT detection protocols in veterinary meat inspection.
    • The study provides crucial data for EU regulatory bodies concerning livestock product safety.