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Related Experiment Videos

Contribution of RGD sequence to neuronal migration in developing cerebral cortex

T Hatta1, O Tanaka, H Otani

  • 1Department of Anatomy Shimane Medical University, Izumo, Japan.

Neuroreport
|November 21, 1994
PubMed
Summary

The Arg-Gly-Asp (RGD) sequence is vital for neuronal migration and proliferation during mammalian brain development. Injecting RGD peptide into developing mouse embryos disrupted cortical plate formation, confirming its role in telencephalon development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The Arg-Gly-Asp (RGD) sequence binds integrins, inhibiting neuronal cell adhesion and migration in vitro.
  • The role of the RGD sequence in in vivo neuronal precursor migration during mammalian cortical histogenesis remains unclear.

Purpose of the Study:

  • To investigate the involvement of the RGD sequence in neuronal migration and proliferation within the developing mammalian telencephalon.

Main Methods:

  • In vivo administration of a synthetic RGD peptide into the telencephalic vesicle of mouse embryos.
  • Histological analysis of the developing cortical plate.
  • BrdU-immunohistochemistry to assess cell proliferation.

Main Results:

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  • Injection of the RGD peptide led to a hypoplastic cortical plate.
  • Histological and BrdU analyses demonstrated that the RGD sequence is implicated in neuronal migration and proliferation.

    • Conclusions:

    • The RGD sequence plays a crucial role in neuronal migration and proliferation during telencephalon development and cortical plate formation in vivo.